human brain tissue were subjected to SDS PAGE followed by western blot with FNab05634(NDUFS7 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human gastric cancer using FNab05634(NDUFS7 antibody) at dilution of 1:100
Immunofluorescent analysis of Hela cells, using FNab05634(NDUFS7 antibody) at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Background
This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions.