Products
MYL2 antibody
- Product Name
- MYL2 antibody
- Catalogue No.
- FNab05486
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- myosin, light chain 2, regulatory, cardiac, slow
- Alternative Names
- MLC2 antibody
- UniProt ID
- P10916
- Observed MW
- 18-20 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
rat heart tissue were subjected to SDS PAGE followed by western blot with FNab05486(MYL2 Antibody) at dilution of 1:5000
Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab05486(MYL2 Antibody) at dilution of 1:50
- Background
- Contractile protein that plays a role in heart development and function(By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force(By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly(By similarity).
