Products
MTF2 antibody
- Product Name
- MTF2 antibody
- Catalogue No.
- FNab05397
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- metal response element binding transcription factor 2
- Alternative Names
- hPCl2 antibody, M96 antibody, MTF2 antibody, PCL2 antibody, Polycomb like protein 2 antibody, RP5 976O13.1 antibody
- UniProt ID
- Q9Y483
- Observed MW
- 60-61 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:200
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05397(MTF2 antibody) at dilution of 1:600
IP Result of anti-MTF2 (IP:FNab05397, 4ug; Detection:FNab05397 1:300) with mouse skeletal muscle tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human brain using FNab05397(MTF2 antibody) at dilution of 1:50
- Background
- Polycomb group(PcG) that specifically binds histone H3 trimethylated at 'Lys-36'(H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element(MRE) of MT1A gene promoter(By similarity).
