Products
MNAT1 antibody
- Product Name
- MNAT1 antibody
- Catalogue No.
- FNab05252
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- menage a trois homolog 1, cyclin H assembly factor(Xenopus laevis)
- Alternative Names
- CAP35 antibody, MAT1 antibody, RNF66 antibody
- UniProt ID
- P51948
- Observed MW
- 36 kDa
Application
- Tested Applications
- ELISA, WB, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab05252(MNAT1 antibody) at dilution of 1:500
IP Result of anti-MNAT1 (IP:FNab05252, 4ug; Detection:FNab05252 1:500) with HeLa cells lysate 1200ug.
- Background
- Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase(CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain(CTD) of its large subunit(POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
