Products
MMP13 antibody
- Product Name
- MMP13 antibody
- Catalogue No.
- FNab05235
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- matrix metallopeptidase 13(collagenase 3)
- Alternative Names
- CLG3 antibody, Collagenase 3 antibody, Matrix metalloproteinase 13 antibody, MMP 13 antibody, MMP13 antibody
- UniProt ID
- P45452
- Observed MW
- 54kd,70kd
Application
- Tested Applications
- ELISA, IHC, WB, IF
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab05235(MMP13 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human breast cancer using FNab05235(MMP13 antibody) at dilution of 1:50
- Background
- Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.It can detect the glycosylated proMMP-13(70 kDa), unglycosylated proform(54 kDa).
