Products
MLXIP antibody
- Product Name
- MLXIP antibody
- Catalogue No.
- FNab05223
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- MLX interacting protein
- Alternative Names
- BHLHE36 antibody, KIAA0867 antibody, MIR antibody, MONDOA antibody
- UniProt ID
- Q9HAP2
- Observed MW
- 130 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
K-562 cells were subjected to SDS PAGE followed by western blot with FNab05223(MLXIP antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human skeletal muscle using FNab05223(MLXIP antibody) at dilution of 1:100
- Background
- Mlx-interacting protein(MLXIP), after forming heterodimers with MLX, can bind to and then activate transcription from CACGTG E boxes. The N terminus of MLXIP acts as a CRM1-dependent nuclear export signal and contribute to the cytoplasmic localization of the complex, and as a binding site for 13 protein. the C terminus contains a cytoplasmic localization signal and mediates protein-protein interaction of MONDOA and MLX. The complex play a role in transcriptional activation of glycolytic target genes and glucose-responsive gene regulation. This antibody could recognize isoform1(~110kd) and isoform3(~69kd) of MLXIP. A specific MLXIP of approximately 130 kDa was detected. It demonstrates that MLXIP associated specifically with Mlx in the cytoplasm (PMID: 11073985).
