HepG2 cells were subjected to SDS PAGE followed by western blot with FNab05217( MLKL Antibody) at dilution of 1:1000
Background
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.