Products
MITF antibody
- Product Name
- MITF antibody
- Catalogue No.
- FNab05198
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- microphthalmia-associated transcription factor
- Alternative Names
- bHLHe32 antibody, MI antibody, MITF antibody, WS2A antibody
- UniProt ID
- O75030
- Observed MW
- 60-65kd
Application
- Tested Applications
- ELISA, WB, FC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:2000
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05198(MITF antibody) at dilution of 1:400
IP Result of anti-MITF (IP: FNab05198, 4ug; Detection: FNab05198 1:1000) with mouse heart tissue lysate 4000ug.
- Background
- Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences(E-boxes)(5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase(TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase(TYR) and tyrosinase-related protein 1(TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
