Hela cells were subjected to SDS PAGE followed by western blot with FNab05175(MIB2 antibody) at dilution of 1:1000
Background
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors(By similarity).