Products
MEK5 antibody
- Product Name
- MEK5 antibody
- Catalogue No.
- FNab05117
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- mitogen-activated protein kinase kinase 5
- Alternative Names
- HsT17454 antibody, MAP kinase kinase 5 antibody, MAP2K5 antibody, MAPK/ERK kinase 5 antibody, MAPKK 5 antibody, MAPKK5 antibody, MEK 5 antibody, MEK5 antibody, MKK5 antibody, PRKMK5 antibody
- UniProt ID
- Q13163
- Observed MW
- 50kd
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab05117(MAP2K5 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human heart using FNab05117(MAP2K5 antibody) at dilution of 1:50
Immunofluorescent analysis of U2OS cells, using MAP2K5 antibody FNab05117 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Background
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms(aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
