Products
MCM7 antibody
- Product Name
- MCM7 antibody
- Catalogue No.
- FNab05062
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- minichromosome maintenance complex component 7
- Alternative Names
- CDC47 antibody, MCM2 antibody
- UniProt ID
- P33993
- Observed MW
- 81 kDa
Application
- Tested Applications
- ELISA, WB, IP, IHC
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab05062(MCM7 Antibody) at dilution of 1:3000
IP Result of anti-MCM7 (IP:FNab05062, 4ug; Detection:FNab05062 1:2000) with NIH/3T3 cells lysate 1600ug.
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab05062(MCM7 Antibody) at dilution of 1:50
- Background
- Acts as component of the MCM2-7 complex(MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
