HepG2 cells were subjected to SDS PAGE followed by western blot with FNab05055(MCM10 antibody) at dilution of 1:300
Background
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38(PubMed:24726359).