Various lysates were subjected to SDS PAGE followed by western blot with FNab05010(Marcksl1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human lung cancer using FNab05010(MARCKSL1 antibody) at dilution of 1:50
Background
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems(By similarity).