Products
LONP1 antibody
- Product Name
- LONP1 antibody
- Catalogue No.
- FNab04821
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 9H10
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- lon peptidase 1, mitochondrial
- Alternative Names
- PRSS15 antibody
- UniProt ID
- P36776
- Observed MW
- 100 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:10000; IHC: 1:400-1:1600; IF: 1:10-1:100
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04821(LONP1 Antibody) at dilution of 1:5000
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab04821(LONP1 Antibody) at dilution of 1:800 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- Background
- ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory(StAR) protein.
