Products
LGR6 antibody
- Product Name
- LGR6 antibody
- Catalogue No.
- FNab04766
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- leucine-rich repeat-containing G protein-coupled receptor 6
- Alternative Names
- FLJ14471 antibody, GPCR antibody, LGR6 antibody, VTS20631 antibody
- UniProt ID
- Q9HBX8
- Observed MW
- 104 kDa
Application
- Tested Applications
- ELISA, IHC, WB, FC
- Recommended dilution
- WB: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab04766(LGR6 antibody) at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis using FNab04766(LGR6 antibody) at dilution of 1:50
- Background
- Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
