Products
LGR5 antibody
- Product Name
- LGR5 antibody
- Catalogue No.
- FNab04765
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- leucine-rich repeat-containing G protein-coupled receptor 5
- Alternative Names
- FEX antibody, G protein coupled receptor 49 antibody, G protein coupled receptor 67 antibody, GPR49 antibody, GPR67 antibody, GRP49 antibody, HG38 antibody, LGR5 antibody
- UniProt ID
- O75473
- Observed MW
- 92-120kd
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:100-1:400
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab04765(LGR5 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human small intestine using FNab04765(LGR5 antibody) at dilution of 1:200
- Background
- Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
