Products
KLHL22 antibody
- Product Name
- KLHL22 antibody
- Catalogue No.
- FNab04620
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- kelch-like 22(Drosophila)
- UniProt ID
- Q53GT1
- Observed MW
- 72 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:2000
Validated Images
mouse brain tissue?were subjected to SDS PAGE followed by western blot with FNab04620(KLHL22 antibody) at dilution of 1:3000
- Background
- Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint(SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
