HeLa cells were subjected to SDS PAGE followed by western blot with FNab04597(KLF10 antibody) at dilution of 1:100
IP Result of anti-KLF10 (IP:FNab04597, 4ug; Detection:FNab04597 1:300) with Jurkat cells lysate 2800ug.
Background
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis(By similarity). May play a role in the cell cycle regulation.