Products
KIF7 antibody
- Product Name
- KIF7 antibody
- Catalogue No.
- FNab04570
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- kinesin family member 7
- Alternative Names
- KIF7 antibody, kinesin family member 7 antibody, Kinesin like protein KIF7 antibody, UNQ340 antibody
- UniProt ID
- Q2M1P5
- Observed MW
- 150 kDa
Application
- Tested Applications
- ELISA, IP, WB
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:1000
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab04570( KIF7 Antibody) at dilution of 1:1000
IP Result of anti-KIF7 (IP: FNab04570, 4ug; Detection: FNab04570 1:500) with HEK-293 cells lysate 2000ug.
- Background
- Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity).
