Products
KEAP1 antibody
- Product Name
- KEAP1 antibody
- Catalogue No.
- FNab04517
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 9E2
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- kelch-like ECH-associated protein 1
- Alternative Names
- INRF2 antibody, KIAA0132 antibody, KLHL19 antibody
- UniProt ID
- Q14145
- Observed MW
- 55-70 kDa
Application
- Tested Applications
- ELISA, IHC, WB, IF
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab04517(KEAP1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab04517(KEAP1 antibody) at dilution of 1:100
- Background
- Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
