Products
KCNIP3 antibody
- Product Name
- KCNIP3 antibody
- Catalogue No.
- FNab04488
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Kv channel interacting protein 3, calsenilin
- Alternative Names
- CSEN antibody, DREAM antibody, KCHIP3 antibody
- UniProt ID
- Q9Y2W7
- Observed MW
- 29 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab04488(KCNIP3 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human gliomas using FNab04488(KCNIP3 antibody) at dilution of 1:50
- Background
- Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception(By similarity). Regulatory subunit of Kv4/D(Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
