Products
KCNAB2 antibody
- Product Name
- KCNAB2 antibody
- Catalogue No.
- FNab04479
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- potassium voltage-gated channel, shaker-related subfamily, beta member 2
- Alternative Names
- KCNA2B antibody, KCNK2 antibody
- UniProt ID
- Q13303
- Observed MW
- 38kd
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500 - 1:2000
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04479 (KCNAB2 antibody) at dilution of 1:1000
- Background
- Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits(PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability(By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity(By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore(PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure(PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5(By similarity). Enhances KCNB2 channel activity(By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity(By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal(in vitro)(By similarity).
