Products
JAML antibody
- Product Name
- JAML antibody
- Catalogue No.
- FNab04436
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- adhesion molecule, interacts with CXADR antigen 1
- Alternative Names
- AMICA1 antibody
- UniProt ID
- Q86YT9
- Observed MW
- 30kd,44kd,50-60kd
Application
- Tested Applications
- ELISA, WB, IHC, IF, FC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
HL-60 cells were subjected to SDS PAGE followed by western blot with FNab04436(AMICA1 antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human spleen using FNab04436(AMICA1 antibody) at dilution of 1:100
- Background
- Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
