Products
ITM2C antibody
- Product Name
- ITM2C antibody
- Catalogue No.
- FNab04419
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 5D9
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- integral membrane protein 2C
- Alternative Names
- BRI3 antibody
- UniProt ID
- Q9NQX7
- Observed MW
- 35 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:500-1:1000; IF: 1:20-1:200
验证图片
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04419(ITM2C antibody) at dilution of 1:600
- Background
- Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation(By similarity).