Products
ITM2C antibody
- Product Name
- ITM2C antibody
- Catalogue No.
- FNab04418
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- integral membrane protein 2C
- Alternative Names
- BRI3 antibody
- UniProt ID
- Q9NQX7
- Observed MW
- 30 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab04418(ITM2C Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab04418(ITM2C Antibody) at dilution of 1:50
- Background
- Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation(By similarity).
