Products
IRF9 antibody
- Product Name
- IRF9 antibody
- Catalogue No.
- FNab04397
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interferon regulatory factor 9
- Alternative Names
- interferon regulatory factor 9 antibody, IRF 9 antibody, IRF9 antibody, ISGF 3 gamma antibody, ISGF3 antibody, ISGF3 p48 subunit antibody, ISGF3G antibody, p48 antibody
- UniProt ID
- Q00978
- Observed MW
- 48kd
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200
Validated Images
mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab04397(IRF9 antibody) at dilution of 1:500
IP Result of anti-IRF9 (IP:FNab04397, 4ug; Detection:FNab04397 1:500) with mouse heart tissue lysate 3200ug.
Immunohistochemistry of paraffin-embedded human cervical cancer using FNab04397(IRF9 antibody) at dilution of 1:50
- Background
- Transcription factor that mediates signaling by type I IFNs(IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases(TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
