Products
Integrin alpha-4 antibody
- Product Name
- Integrin alpha-4 antibody
- Catalogue No.
- FNab04346
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- integrin, alpha 4
- Alternative Names
- CD49D antibody, IA4 antibody, Integrin alpha 4 antibody, Integrin alpha IV antibody, ITGA4 antibody, VLA 4 subunit alpha antibody
- UniProt ID
- P13612
- Observed MW
- 140 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1500-1:2000; IHC: 1:20-1:200
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04346(ITGA4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab04346(Integrin alpha-4 Antibody) at dilution of 1:50
- Background
- ITGA4, also named as CD49D, belongs to the integrin alpha chain family. ITGA4 is a receptor for fibronectin, VCAM1 and MADCAM1. ITGA4 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. It recognizes the sequence Q-I-D-S in VCAM1. I It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells ITGA4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
