Products
ING4 antibody
- Product Name
- ING4 antibody
- Catalogue No.
- FNab04313
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- inhibitor of growth family, member 4
- Alternative Names
- ING4 antibody, Inhibitor of growth protein 4 antibody, my036 antibody, P29ing4 antibody
- UniProt ID
- Q9UNL4
- Observed MW
- 29kd
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200; IP: 1:200-1:2000
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab04313(ING4 antibody) at dilution of 1:1000
IP Result of anti-ING4 (IP:FNab04313, 3ug; Detection:FNab04313 1:200) with HEK-293 cells lysate 2700ug.
Immunohistochemistry of paraffin-embedded human brain using FNab04313(ING4 antibody) at dilution of 1:100
- Background
- Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's(HIF) activity by interacting with HIF prolyl hydroxylase 2(EGLN1). Can enhance aopotosis induced by serum starvation in mammary epithelial cell line HC11(By similarity).
