human heart tissue were subjected to SDS PAGE followed by western blot with FNab04303(IMPDH2 antibody) at dilution of 1:400
IP Result of anti-IMPDH2 (IP:FNab04303, 3ug; Detection:FNab04303 1:800) with K-562 cells lysate 4000ug.
Immunohistochemistry of paraffin-embedded human lung cancer using FNab04303(IMPDH2 antibody) at dilution of 1:100
Background
Catalyzes the conversion of inosine 5'-phosphate(IMP) to xanthosine 5'-phosphate(XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.