Products
IL33 antibody
- Product Name
- IL33 antibody
- Catalogue No.
- FNab04272
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 4E8
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interleukin 33
- Alternative Names
- C9orf26 antibody, IL1F11 antibody, NFHEV antibody
- UniProt ID
- O95760
- Observed MW
- 35kd
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:50-1:500
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04272(IL33 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human nasopharyngeal carcinoma tissue slide using FNab04272(IL33 Antibody) at dilution of 1:200
- Background
- Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells(PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury(PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets(PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation(PubMed:18787100).
