Products
IKZF1 antibody
- Product Name
- IKZF1 antibody
- Catalogue No.
- FNab04204
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- IKAROS family zinc finger 1(Ikaros)
- Alternative Names
- IK1 antibody, IKAROS antibody, LYF1 antibody, ZNFN1A1 antibody
- UniProt ID
- Q13422
- Observed MW
- 57-70 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab04204(IKZF1 antibody) at dilution of 1:500
IP Result of anti-IKZF1 (IP:FNab04204, 4ug; Detection:FNab04204 1:500) with HeLa cells lysate 1200ug.
Immunohistochemistry of paraffin-embedded human lymphoma using FNab04204(IKZF1 antibody) at dilution of 1:50
- Background
- Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).
