HL-60 cells were subjected to SDS PAGE followed by western blot with FNab04197(NFKBIA antibody) at dilution of 1:500
IP Result of anti-IkB alpha (IP:FNab04197, 5ug; Detection:FNab04197 1:500) with HeLa cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human cervical cancer slide using FNab04197(NFKBIA Antibody) at dilution of 1:200
Background
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.