Products
IFT57 antibody
- Product Name
- IFT57 antibody
- Catalogue No.
- FNab04160
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- intraflagellar transport 57 homolog(Chlamydomonas)
- Alternative Names
- DERP8 antibody, ESRRBL1 antibody, HIPPI antibody
- UniProt ID
- Q9NWB7
- Observed MW
- 49kd
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
mouse retina tissue were subjected to SDS PAGE followed by western blot with FNab04160(IFT57 antibody) at dilution of 1:1000
IP Result of anti-IFT57 (IP:FNab04160, 5ug; Detection:FNab04160 1:800) with HEK-293 cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab04160(IFT57 antibody) at dilution of 1:50
- Background
- Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway(By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8(CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
