Products
IFIT2 antibody
- Product Name
- IFIT2 antibody
- Catalogue No.
- FNab04137
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interferon-induced protein with tetratricopeptide repeats 2
- Alternative Names
- cig42 antibody, G10P2 antibody, GARG 39 antibody, IFI 54 antibody, IFI 54K antibody, IFI54 antibody, IFIT 2 antibody, IFIT2 antibody, ISG 54 K antibody, ISG 54K antibody, ISG54 antibody
- UniProt ID
- P09913
- Observed MW
- 50-55 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Validated Images
A431 cells were subjected to SDS PAGE followed by western blot with FNab04137(IFIT2 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab04137(IFIT2 Antibody) at dilution of 1:50
Immunofluorescent analysis of HepG2 cells using FNab04137 (IFIT2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
