Products
Iduronate 2 sulfatase antibody
- Product Name
- Iduronate 2 sulfatase antibody
- Catalogue No.
- FNab04130
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG1
- Clone ID
- 2D2
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- iduronate 2-sulfatase
- Alternative Names
- IDS antibody, iduronate 2 sulfatase antibody, Idursulfase antibody
- UniProt ID
- P22304
- Observed MW
- 76 kDa, 55 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab04130(IDS antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human liver slide using FNab04130(IDS Antibody) at dilution of 1:50
- Background
- Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).
