Products
IDO1 antibody
- Product Name
- IDO1 antibody
- Catalogue No.
- FNab04127
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- indoleamine 2,3-dioxygenase 1
- Alternative Names
- CD107B antibody, IDO antibody, IDO 1 antibody, IDO1 antibody, INDO antibody, indoleamine 2 antibody, 3 dioxygenase 1 antibody
- UniProt ID
- P14902
- Observed MW
- 42 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:1000-1:4000; IHC: 1:50-1:500
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab04127( IDO1 Antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab04127( IDO1 Antibody) at dilution of 1:100
- Background
- Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway(PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses(PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells(PubMed:25691885). Acts as a suppressor of anti-tumor immunity(PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immune rejection(PubMed:25691885).
