Products
HP antibody
- Product Name
- HP antibody
- Catalogue No.
- FNab03990
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 7C8
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- haptoglobin
- Alternative Names
- BP antibody, HAPT antibody, haptoglobin antibody, HP antibody, HP2 ALPHA 2 antibody, HPA1S antibody, Zonulin antibody
- UniProt ID
- P00738
- Observed MW
- 42 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:2000 - 1:20000
Validated Images
0.5 μl human plasma was subjected to SDS PAGE followed by western blot with FNab03990 (HP Antibody) at dilution of 1:20000
- Background
- As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
