Products
HOMER1 antibody
- Product Name
- HOMER1 antibody
- Catalogue No.
- FNab03963
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- homer homolog 1(Drosophila)
- Alternative Names
- SYN47 antibody
- UniProt ID
- Q86YM7
- Observed MW
- 46-48 kDa
Application
- Tested Applications
- ELISA, WB, FC, IHC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab03963(HOMER1 antibody) at dilution of 1:1000
IP result of anti-HOMER1(IP:FNab03963, 4ug; Detection:FNab03963 1:1000) with fetal human brain tissue lysate 4000 ug
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab03963(HOMER1 Antibody) at dilution of 1:50
- Background
- Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
