Products
HEY1 antibody
- Product Name
- HEY1 antibody
- Catalogue No.
- FNab03849
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- hairy/enhancer-of-split related with YRPW motif 1
- Alternative Names
- BHLHB31 antibody, CHF2 antibody, HERP2 antibody, HESR1 antibody, HRT1 antibody
- UniProt ID
- Q9Y5J3
- Observed MW
- 33 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
DU 145 cells were subjected to SDS PAGE followed by western blot with FNab03849(HEY1 antibody) at dilution of 1:3000
IP Result of anti-HEY1 (IP:FNab03849, 4ug; Detection:FNab03849 1:500) with mouse kidney tissue lysate 4400ug.
Immunohistochemistry of paraffin-embedded human brain using FNab03849(HEY1 antibody) at dilution of 1:100
- Background
- Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).
