Products
GRIA4 antibody
- Product Name
- GRIA4 antibody
- Catalogue No.
- FNab03646
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- glutamate receptor, ionotrophic, AMPA 4
- Alternative Names
- GLUR4 antibody
- UniProt ID
- P48058
- Observed MW
- 101 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
rat brain tissue were subjected to SDS PAGE followed by western blot with FNab03646(GRIA4 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab03646(GRIA4 Antibody) at dilution of 1:50
- Background
- Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
