Products

GRB7 antibody

Catalogue No.:FNab03643Reativity:Human, Mouse
Host:RabbitTested Application:ELISA, WB, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
GRB7 antibody
Catalogue No.
FNab03643
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
growth factor receptor-bound protein 7
UniProt ID
Q14451
Observed MW
60-70 kDa
Application
Tested Applications
ELISA, WB, IP
Recommended dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Validated Images
A431 cells were subjected to SDS PAGE followed by western blot with FNab03643(GRB7 antibody) at dilution of 1:1000
IP Result of anti-GRB7 (IP:FNab03643, 3ug; Detection:FNab03643 1:500) with A431 cells lysate 3300ug.
Background
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress(By similarity).