Products
GRB14 antibody
- Product Name
- GRB14 antibody
- Catalogue No.
- FNab03641
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- growth factor receptor-bound protein 14
- UniProt ID
- Q14449
- Observed MW
- 61kd
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
DU 145 cells were subjected to SDS PAGE followed by western blot with FNab03641(GRB14 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab03641(GRB14 antibody) at dilution of 1:50
- Background
- Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor(INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
