Products
GRB10 antibody
Category:
Research Area:
Synonyms: | Grb 10 antibody, GRB IR antibody, GRB10 antibody, GRB10 adapter protein antibody, GRBIR antibody, IRBP antibody, KIAA0207 antibody, MEG1 antibody, RSS antibody | ||
Catalogue No.: | FNab03640 | Reactivity: | Human, Mouse, Rat |
Host: | Rabbit | Tested Application: | ELISA, WB, IF, IHC |
Clonality: | polyclonal | Isotype: | IgG |
- SPECIFICATIONS
- Product Name
- GRB10 antibody
- Catalogue No.
- FNab03640
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- growth factor receptor-bound protein 10
- Alternative Names
- Grb 10 antibody, GRB IR antibody, GRB10 antibody, GRB10 adapter protein antibody, GRBIR antibody, IRBP antibody, KIAA0207 antibody, MEG1 antibody, RSS antibody
- UniProt ID
- Q13322
- Observed MW
- 65 kDa
Application
- Tested Applications
- ELISA, WB, IF, IHC
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab03640(GRB10 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human liver slide using FNab03640(GRB10 Antibody) at dilution of 1:50
- Background
- Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin(INSR) and insulin-like growth factor(IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.