Products
GM2A antibody
- Product Name
- GM2A antibody
- Catalogue No.
- FNab03517
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- GM2 ganglioside activator
- UniProt ID
- P17900
- Observed MW
- 22 kDa
Application
- Tested Applications
- ELISA, IHC, WB, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
rat kidney tissue were subjected to SDS PAGE followed by western blot with FNab03517(GM2A Antibody) at dilution of 1:300
IP Result of anti-GM2A (IP:FNab03517, 3ug; Detection:FNab03517 1:600) with HEK-293 cells lysate 2800ug.
Immunohistochemistry of paraffin-embedded human colon cancer using FNab03517(GM2A antibody) at dilution of 1:100
- Background
- The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity(By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
