mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab03296(GADD45GIP1 antibody) at dilution of 1:300
IP Result of anti-GADD45GIP1 (IP:FNab03296, 4ug; Detection:FNab03296 1:400) with mouse heart tissue lysate 4000ug.
Background
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.