HeLa cells were subjected to SDS PAGE followed by western blot with FNab03224(FRK antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human breast cancer using FNab03224(FRK antibody) at dilution of 1:50
Background
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.