HeLa cells were subjected to SDS PAGE followed by western blot with FNab03041(FBXO22 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human tonsil using FNab03041(FBXO22 antibody) at dilution of 1:50
Background
Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin(ACTN2) and filamin-C(FLNC), essential for maintenance of normal contractile function.