Products
FBXO2 antibody
- Product Name
- FBXO2 antibody
- Catalogue No.
- FNab03040
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- F-box protein 2
- Alternative Names
- FBX2 antibody
- UniProt ID
- Q9UK22
- Observed MW
- 33-40 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
Validated Images
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab03040(FBXO2 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human brain using FNab03040(FBXO2 antibody) at dilution of 1:50
- Background
- Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type(By similarity).
