Products

anti- FAM175A antibody

FNab02974 Catalogue No.
Synonyms
ABRA1, CCDC98
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB, IHC, IF
Product Information
Product Name
anti- FAM175A antibody
Catalogue No.
FNab02974
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Immunogen Information
Immunogen
family with sequence similarity 175, member A
Synonyms
ABRA1, CCDC98
Observed MW
46 kDa
Application
Tested Application
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500-1:2400; IHC: 1:20-1:200; IF: 1:20-1:200
Uniprot information
UniProt ID
Q6UWZ7
Images
Immunohistochemistry of paraffin-embedded human breast cancer using FNab02974 (FAM175A antibody) at dilution of 1:100
human testis tissue were subjected to SDS PAGE followed by western blot with FNab02974 (FAM175A antibody) at dilution of 1:500