Products

FAM175A antibody

Synonyms:ABRA1 antibody, CCDC98 antibody
Catalogue No.:FNab02974Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
FAM175A antibody
Catalogue No.
FNab02974
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
family with sequence similarity 175, member A
Alternative Names
ABRA1 antibody, CCDC98 antibody
UniProt ID
Q6UWZ7
Observed MW
46 kDa
Application
Tested Applications
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500-1:2400; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
human testis tissue were subjected to SDS PAGE followed by western blot with FNab02974(FAM175A antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human breast cancer using FNab02974(FAM175A antibody) at dilution of 1:100
Background
Involved in DNA damage response and double-strand break(DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.